Brugada Syndrome (BrS) presents a particularly challenging clinical field for cardiologists due to its associated potentially lethal and often unpredictable arrhythmic risk [1]. While secondary prevention in patients with documented ventricular arrhythmias is relatively straightforward, leading to the inevitable implantation of an implantable cardioverter-defibrillator (ICD), primary prevention is more debated. The challenge lies in effectively protecting the patient from sudden cardiac death (SCD) while avoiding overtreatment and potential complications from defibrillator implantation [2].

In contemporary times, the pursuit of minimalism has gained ascendancy, surpassing the trend table and permeating into various facets of life, such as architecture, interior design, economics, and notably, science. Within the realm of science, this inclination is recognized as nanoscience, wherein the focus is on the study of matter at the nanoscale. Nanotechnology, a branch of nanoscience, is concerned with the synthesis, manipulation, and application of nanomaterials and nanoparticles in technology.

This scholarly work aims to provide a comprehensive exploration of the multifarious uses of nanotechnology in the domain of medicine. The study delves into the vast applications of nanotechnology in medicine, with a view to understanding the strides that have been made in enhancing the quality of the medical field and improving the well-being of patients’ post-treatment. The diverse aspects of medicine scrutinized in this research encompass but are not limited to dentistry, surgery, drug delivery methods, antibiotics, and regenerative medicine.

Despite the potential of nanotechnology to revolutionize the field of medicine by offering expedited treatment options for various ailments and even purportedly speeding up the healing of wounds and burns, it is essential to acknowledge that like any other scientific innovation, it also possesses its share of drawbacks and constraints. The application of nanotechnology in medicine may present certain limitations and disadvantages that must be taken into consideration when assessing its overall impact on patient care and treatment outcomes.

Keywords: Nanotechnology; nanoscience; medicine; nanoparticles; nanomaterials

About the movie “The Priest's Children,” [1] controversial criticism has been written [2]. Some praise it as one of the best Croatian comedies [3], while others attack it [4], mostly due to its alleged criticism of the Church and the use of clichés [5]. Probably both sides are right. However, in my opinion, the film's deep moral side remains underestimated.

The story unfolds through a lengthy confession, illustrating how a new priest on a small Croatian island tries to increase fertility—by ensuring that all the condoms sold at the kiosk are defective.

The study examined the impact of Rauwolfia vomitoria Oliv. ethanol and aqueous root extracts on tocopherol, adenine deaminase, and antioxidant parameters in arthritic albino rats. A complete set of 135 albino rats were used in this investigation. Nine groups, each including fifteen rats, were formed from the rats. The albino rats' left hind foot was intradermally administered with 0.1 millilitres of Chicken type 11 collagen-Complete Freund's adjuvant to trigger arthritis. On the 10th day of arthritis induction, administration with the extract at dosages of 400, 600, and 800 mg/ kg body weight began. The 32-day research was conducted, and the spectrophotometric technique was used to obtain the results. Our findings demonstrated that the RA rats had considerably higher (P<0.05) concentrations of malondialdehyde (MDA ) and nitric oxide (NO) than the normal control rats, but considerably decreased (P<0.05) levels of glutathione peroxidase, catalase, superoxide dismutase (SOD), reduced glutathione, and tocopherol. Nevertheless, treatment of RA rats with the extracts caused a reversal of the observed effects. The extracts' ability to relieve the arthritic rats' symptoms depended on both time and dosage. The conventional medicine (indomethacine) and the root extracts have considerably (P<0.05) equivalent anti-arthritic abilities. The findings demonstrated that the ethanol and aqueous root extracts of Rauwofia vomitoria possess components that may have improved the arthritic rats' antioxidant levels, reduced oxidative stress, and reversed the arthritic conditions brought on by adjuvant-induced arthritic rats. Therefore, the current study offers proof from science that the ethanol and aqueous root extracts of Rauwolfia vomitoria include compounds that may be used to treat arthritis.

Keywords: Rauwolfia vomitoria; Tocopherol; Adenine deaminase; Antioxidant potentials; Nitric oxide and Arthritis

After around two years of COVID-19 pandemic, it is well- known that COVID-19 affects mainly the respiratory system. However, our case presents a young female patient aged (30) admitted to the emergency department (ER) complaining of fever, altered mental status and seizures. The patient had no respiratory manifestations. She was managed with antipyretics and anti-epileptics. Although coronavirus commonly affect the respiratory system, this case shed a light on the neurological manifestations which may the patient suffer from due to COVID-19 infection.

Keywords: Covid-19; Coronavirus; Seizures; Epilepsy; Pandemic

Homocysteine is a derived sulfur, non-proteinogenic amino acid (1). Hyperhomocysteinemia is a risk factor for vascular and neurodegenerative ocular diseases eg retinopathies, glaucoma, maculopathies, cataract.

Optic neuropathy and retinal vascular diseases. This is because of impaired vascular endothelial function, apoptosis of retinal ganglion cells and oxidative stress (2).

Hyperhomocysteinemia poses metabolic disorder in which there is high level of homocysteine caused by deficiency of cystathionine- beta synthase, metiionine synthase, vitamin B6 and B12 (3).

Patients may supplement with these vitamins to lessen the ocular morbidity.

This article discusses the association of hyperhomocysteinemia in ocular problems and possible mechanism in pathogenesis which may help in proper management.

Keywords: Hyperhomocyseinemia; diabetic retinopathy; Glaucoma; Optic neuropathy; Cataract; Vit B12