Abstract

The study examined the impact of Rauwolfia vomitoria Oliv. ethanol and aqueous root extracts on tocopherol, adenine deaminase, and antioxidant parameters in arthritic albino rats. A complete set of 135 albino rats were used in this investigation. Nine groups, each including fifteen rats, were formed from the rats. The albino rats' left hind foot was intradermally administered with 0.1 millilitres of Chicken type 11 collagen-Complete Freund's adjuvant to trigger arthritis. On the 10th day of arthritis induction, administration with the extract at dosages of 400, 600, and 800 mg/ kg body weight began. The 32-day research was conducted, and the spectrophotometric technique was used to obtain the results. Our findings demonstrated that the RA rats had considerably higher (P<0.05) concentrations of malondialdehyde (MDA ) and nitric oxide (NO) than the normal control rats, but considerably decreased (P<0.05) levels of glutathione peroxidase, catalase, superoxide dismutase (SOD), reduced glutathione, and tocopherol. Nevertheless, treatment of RA rats with the extracts caused a reversal of the observed effects. The extracts' ability to relieve the arthritic rats' symptoms depended on both time and dosage. The conventional medicine (indomethacine) and the root extracts have considerably (P<0.05) equivalent anti-arthritic abilities. The findings demonstrated that the ethanol and aqueous root extracts of Rauwofia vomitoria possess components that may have improved the arthritic rats' antioxidant levels, reduced oxidative stress, and reversed the arthritic conditions brought on by adjuvant-induced arthritic rats. Therefore, the current study offers proof from science that the ethanol and aqueous root extracts of Rauwolfia vomitoria include compounds that may be used to treat arthritis.

Keywords: Rauwolfia vomitoria; Tocopherol; Adenine deaminase; Antioxidant potentials; Nitric oxide and Arthritis

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Citation

Nkiruka N Ezeani. “Actions of Aqueous and Ethanol Root Extracts of Rauwolfia Vomitoria on Tocopherol, Adenine Deaminase and Antioxidant Indices in Complete Freund’s Adjuvant-Chicken Type II Collagen Induced Arthritic Rats". Clareus Scientific Medical Sciences 2.1 (2025): 19-29.

Copyright

© 2025 Nkiruka N Ezeani. Licensee Clareus Scientific Publications. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.