Abstract

Homocysteine is a derived sulfur, non-proteinogenic amino acid (1). Hyperhomocysteinemia is a risk factor for vascular and neurodegenerative ocular diseases eg retinopathies, glaucoma, maculopathies, cataract.

Optic neuropathy and retinal vascular diseases. This is because of impaired vascular endothelial function, apoptosis of retinal ganglion cells and oxidative stress (2).

Hyperhomocysteinemia poses metabolic disorder in which there is high level of homocysteine caused by deficiency of cystathionine- beta synthase, metiionine synthase, vitamin B6 and B12 (3).

Patients may supplement with these vitamins to lessen the ocular morbidity.

This article discusses the association of hyperhomocysteinemia in ocular problems and possible mechanism in pathogenesis which may help in proper management.

Keywords: Hyperhomocyseinemia; diabetic retinopathy; Glaucoma; Optic neuropathy; Cataract; Vit B12

Citation

Swarna Biseria Gupta., et al. “Hyper Homocysteinemia in Ocular Diseases - A Study". Clareus Scientific Medical Sciences 2.1 (2025): 34-38.

Copyright

© 2025 Swarna Biseria Gupta., et al. Licensee Clareus Scientific Publications. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.