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Clareus Scientific Medical Sciences (ISSN: 3064-8017)

Research Article | Volume 3 Issue 1 - 2026

Ab Initio Whole Cell Kinetic Model of Streptococcus pneumoniae NCTC 7465 (spnLHP26)

Leesha Haarshiny Perumal1,2, Atoshi Abirami RajKumar1,2, Cheryl Kai Ning Kang1,2, Sragvi Verma1,2, Diya Nanthakumarvani1,2, Shafeeqa Abul-Hasan1,2 and Maurice HT Ling2,3,4*
1Department of Applied Sciences, Northumbria University, United Kingdom
2Management Development Institute of Singapore, Singapore
3Newcastle Australia Institute of Higher Education, University of Newcastle, Australia
4HOHY PTE LTD, Singapore
*Corresponding Author: Maurice HT Ling, Management Development Institute of Singapore, Singapore; Newcastle Australia Institute of Higher Education, University of Newcastle, Australia; HOHY PTE LTD, Singapore.

 January 26, 2026

DOI: 10.70012/CSMS-03-015

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Abstract

Streptococcus pneumoniae is a pathogen able to utilize various carbon sources to produce polysaccharide capsule to avoid the immune system, leading to responsible for many life-threatening infections. Kinetic models may be used to examine S. pneumoniae’s carbon utilization but there are no whole-cell kinetic models of S. pneumoniae to date. In this study, we construct a whole-cell kinetic model based on S. pneumoniae NCTC 7465 using its annotated genome. The resulting model, spnLHP26, consists of 460 enzymes catalysing 836 reactions involving 163 metabolites; which may be suitable as a baseline draft model to examine virulence-associated metabolic susceptibilities of S. pneumoniae.

Keywords: Whole-cell model; Kinetic model; Differential equations; AdvanceSyn Toolkit

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Citation

Maurice HT Ling., et al. “Ab Initio Whole Cell Kinetic Model of Streptococcus pneumoniae NCTC 7465 (spnLHP26)". Clareus Scientific Medical Sciences 3.1 (2026): 02-07.

Copyright

© 2026 Maurice HT Ling., et al. Licensee Clareus Scientific Publications. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.

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