Abstract

In recent years, Organ failure and severe tissue damage have been critical medical challenges due to traumatic injuries, the lack of organs for transplantation, and the inherent limitations of conventional artificial implants. To overcome these obstacles, tissue engineering and regenerative medicine have highlighted the urgent need for a transformative approach to the living body that maintains, restores, and improves tissue function. Stem cells serve as the cornerstone of Regenerative medicine due to their unique capability to self-renew and differentiate into various cell types (multilineage) contributing a potential resolution to tissue damage and organ shortage of transplantable organs [1]. However, some significant challenges such as low efficiency of differentiation protocols, poor immune compatibility, and high risk of teratoma formation limit clinical translation when the stem cells are used alone. Therefore, the emergence of advanced biomaterials as a transformative outcome offers precise control over the stem cell microenvironment. Engineered biomaterials can control stem cell behavior by creating optimized niches that copy native tissue environments, these bio-material systems increase differentiation efficiency and improve immune toleration. Therefore, the potential of biomaterials for stem cell engineering is playing a gradually important role in regenerative medicine.

References

1. Xu Y., et al. “Biomaterials for stem cell engineering and biomanufacturing”. Bioactive Materials 4 (2019): 366-379.
2. Nugud A., et al. “Biomaterials as a Vital Frontier for Stem Cell-Based Tissue Regeneration”. Frontiers in Cell and Developmental Biology 10 (2022).
3. Singh A and Elisseeff J. “Biomaterials for stem cell differentiation”. Journal of Materials Chemistry 20.40 (2010): 8832-8847.
4. Zhang Y., et al. “Stem Cell-Friendly Scaffold Biomaterials: Applications for Bone Tissue Engineering and Regenerative Medicine”. Frontiers in Bioengineering and Biotechnology 8 (2020).

Citation

Rupa Bargakshatriya. “Biomaterials Engineering in Stem Cell Therapy". Clareus Scientific Science and Engineering 2.7 (2025): 62-63.

Copyright

© 2025 Rupa Bargakshatriya. Licensee Clareus Scientific Publications. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.